OBIDOXIME CHLORIDE
OBIDOXIME CHLORIDE
CAS: 114-90-9
Molecular Formula: C14H16Cl2N4O3
OBIDOXIME CHLORIDE - Names and Identifiers
OBIDOXIME CHLORIDE - Physico-chemical Properties
| Molecular Formula | C14H16Cl2N4O3 |
| Molar Mass | 359.21 |
| Melting Point | 216-219oC dec. |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | neat |
| Color | Off-White to Light Beige |
| BRN | 4117377 |
| Storage Condition | -20°C Freezer |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| In vivo study | Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD 50 of 57.7 mg/kg after administration of sarin, and it reduces reduces acute toxicity of sarin was evaluated. Animal Model: NMRI male mice Dosage: 10 mg/kg Administration: Intramuscular injection Result: Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE). |
OBIDOXIME CHLORIDE - Risk and Safety
| WGK Germany | 2 |
| RTECS | UU6825000 |
| Toxicity | LD50 in mice, rats (mg/kg): 70, 133 i.v.; 150, 225 i.p.; >2240, >4000 orally; in mice (mg/kg): 172 i.m. (Erdman, Engelhard) |
OBIDOXIME CHLORIDE - Reference Information
| biological activity | Obidoxime dichloride is a non-full spectrum oxime reagent that can be used as an antidote for organophosphate neurotoxicity. Obidoxime dichloride can activate acetylcholinesterase (AChE) inhibited by sarin and reduce the acute toxicity of sarin. |
| in vivo study | Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD 50 of 57.7 mg/kg after administration of sarin, and acute toxicity of sarin was evaluated. Animal Model: NMRI male mice Dosage: 10 mg/kg Administration: Intramuscular injection Result: Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE). |
| Animal Model: | NMRI male mice |
| Dosage: | 10 mg/kg |
| Administration: | Intramuscular injection |
| Result: | Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE). |
| category | pesticide |
| toxicity grade | high toxicity |
| Acute toxicity | intraperitoneal-rat LD50:189 mg/kg; Oral-mouse LD50: 2240 mg/kg |
| flammability hazard characteristics | flammability; Toxic NOx and bromide fumes from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-10 22:29:15
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